Obedient to which command, Rudra became twofold, disjoining his male and female natures. From these two were born two sons, Priyavrata. These are all called the inflictors of misery, and are characterised as the progeny of Vice Adharma. On the contrary, Daksha and the other Rishis, the elders of mankind, tend perpetually to influence its renovation: whilst the Manus and their sons, the heroes endowed with mighty power, and treading in the path of truth, as constantly contribute to its preservation.
In the second, the mundane egg resolves into the primary element, from whence it was derived. Absolute non-existence of the world is the absorption of the sage, through knowledge, into supreme spirit. Perpetual destruction is the constant disappearance, day and night, of all that are born. The Uttara Khanda of the Padma P. The Medes formed an important division of the times of the Gentiles as prophesied by Daniel.
They occupy a large share in the prophetic program of the Old Testament leading up to Christ. The height of the power of the Medes, after several centuries of struggle, was reached in the sixth century b. Their notable triumph was the conquering of Babylon in b. The Medes flourished for two centuries thereafter until the time of Alexander the Great. The fourth son of Japheth known as Javan cp. I Chronicles , 7 was the forefather of the Ionians or the Greeks.
Descendants of Javan are mentioned in inscriptions of Assyria and Achaemenia. They were the Hellenists and the word Javan is so translated in the Septuagint. The descendants of Javan are mentioned frequently in the Bible Isaiah ; Ezekiel , 19; Daniel ; ; ; Zechariah The descendants of Javan inhabited Libya, and Caria, the Aegean Islands and the area known in modern history as Greece. As early as the eighth century b. Assyrian records mention a naval battle with the Greeks.
The four sons of Javan, Elishah, Tarshish, Kittim, and Dodanim do not appear as major elements in subsequent history. They exported purple and scarlet fabrics to the market at Tyre, the purple dye being derived from shells rich in this color on the Aegean coasts. As ships were used to carry the smelted ore, frequent mention is made to ships of Tarshish cp. I Kings , 50; II Chronicles , Some believe the term also applies to any large ship regardless of geography Psalm ; Isaiah ; ; Ezekiel It is therefore not clear whether the name Tarshish as the description of a descendant of Javan is the proper meaning in these many references and there may be no racial connection.
Kittim sometimes spelled Chittim , another son of Javan, seems also to refer to the Ionian or Greeks. Although the name with various significations is found in a loose way to refer to the islands and coasts of the Mediterranean without specifying any particular geographic location, the name Kittim occurs with varied spellings elsewhere in the Old Testament cp.
Numbers ; Isaiah , 12; Jeremiah ; ; ; Ezekiel ; Daniel It is not clear to what extent Kittim is related to these references. Dodanim Genesis ; I Chronicles , the fourth son of Javan, is regarded as the progenitor of those who lived in Illyricum and Troy and were closely associated with Kittim. They are relatively unimportant in subsequent Scriptures. The three remaining sons of Japheth are named without posterity, signifying that their descendants did not form an important segment of the human race. Tubal Genesis ; I Chronicles seems to be related to the Scythians.
They are subsequently mentioned in the prophets Isaiah ; Ezekiel ; ; , 3; Prophetically they will join with the invading army of the land of Israel in the last days recorded in Ezekiel It is probable that their modern descendants now live in Russia. Meshech appears in history as early as the twelfth century b.
In Ezekiel , the descendants of Meshech had commercial dealings with Tyre, selling slaves and vessels of bronze. Prophetically, Meshech has a place in the last days as recorded in Ezekiel ; , 3; and is included in the invading army. Tiras the last son of Japheth is mentioned only in the genealogies I Chronicles and it is generally believed that his descendants became the Thracians who inhabited the Aegean coast.
The descendants of Japheth spread out to the north, east, and west, and are probably the progenitors of most of the Northern Europe lands and, hence, of all countries derived from Europe such as the United States and Canada. They formed the major part of the Gentiles or the nations and will have their important role in the chapters of world history which will bring the times of the Gentiles to conclusion. Seba - Ancient Sabeans Gen. Havilah — Modern Yemen Gen. Sabtechah - Inhabited the eastern side of the Persian Gulf Gen.
Some of these may be descriptive nouns rather than names of cities. Mizraim - Egypt and East of Egypt Gen. All these names are plural emphasizing their ethnic character. Some identify them as from Crete cp. Caphtorim - Origin same as Casluhim, possibly inhabited Philistia Gen. Canaan - At the time of the conquest all the land designated as Palestine, west of the Jordan Gen. Sidon - Ancient Phoenicia, city of Sidon Gen. Jebusite - Original inhabitants of Jerusalem Gen. Amorite - Located originally west of the Dead Sea Gen. Hivite - Northern Palestine, Shechem Gen.
Arvadite - Located on an island off the coast of Phoenicia, familiar in Assyrian records Gen. Zemarite - West of Galilee Gen. Hamathite - Upper Syria, at the foot of Lebanon Gen. The sons of Ham occupy a large portion of the Genesis 10 record ; cp. I Chronicles Unquestionably the large space given to the sons of Ham was due to their ultimate relationship to the subsequent history of Israel and the purposes of God in the Middle East. Special mention is made of the sons of Raamah, namely, Sheba and Dedan. The most prominent son of Gush, however, is Nimrod mentioned in Genesis In general the descendants of Ham occupy all of Asia except the northern part, and settled in Southern Europe, and Northern Africa.
They may be the forefathers of the American Indians who are believed to have originally entered the American continent through Alaska, having come up the east coast of Asia. The descendants of Cush seem to have inhabited Southern Egypt and the land to the south and east of Egypt, including ancient Abyssinia, Nubia, and Ethiopia. Because of the close proximity of the Semitic race, the Ethiopian language eventually became Semitic even though the racial origin was otherwise.
The five sons of Cush seem to refer to various peoples in the general geographic area of Egypt. Some of them reached all the way to the Persian Gulf and some mention is made of most of them in various Scriptures: Seba cp. I Chronicles ; Psalm ; Isaiah ; cp.
Genesis ; ; ; I Samuel ; I Chronicles Little is known of Sabtah except that probably it is to the east of Yemen Genesis ; I Chronicles The descendants of Sabtah lived east of Yemen. The descendants of Raamah Genesis ; I Chronicles are mentioned in Ezekiel as famous traders and according to inscriptions were located geographically in Southwest Arabia adjacent to the Persian Gulf. The two sons of Raamah, namely, Sheba and Dedan are usually mentioned together and there is some confusion between Sheba and Seba cp. Seba, above.
Both lived in the general area of Arabia. The special mention of Nimrod Genesis ; I Chronicles ; cp. Micah as a descendant of Cush is occasioned by the fact that he is the originator of Babel later known as Babylon and apparently was an energetic man who with his posterity built the Mesopotamian area and such famous spots as Asshur and Nineveh Genesis Nimrod was unquestionably the Napoleon of his day and the head of one of the earliest empires subsequent to Noah recorded in Scripture. His government seems to have occupied most of Western Asia and has left many monuments.
The political might symbolized in Nimrod and his empire was ended subsequent to the divine judgment at the tower of Babel when their one language was confounded. The second son of Ham, Mizraim, was the progenitor of the major population of Egypt and usually the term is translated Egypt about 87 times in its many instances in the Bible. It is generally agreed, however, that the descendants of Mizraim, of which seven are named Genesis , 14 , migrated to the east and this accounts for the similarity between those who inhabited the area adjacent to the Indian Ocean to the Egyptians.
Ludim apparently refers to the Libyans of Northern Africa. Anamim is mentioned only in the genealogies Genesis ; I Chronicles but probably lived in Northern or Middle Egypt. Lehabim is also mentioned only in the genealogies Genesis ; I Chronicles and they also have been related to the Libyans. In general Mizraim is therefore to be identified with Egypt, but its people migrated extensively to the east.
As one of the important nations related to Israel, they figure largely in subsequent prophecy and form one of the great prophetic themes of the Old Testament which will be the subject of later discussion. From these references it is clear that the people who descended from Phut were Africans closely associated with the descendants of Mizraim. Their exact geographic location, however, is not clear and it may be that they were scattered.
Most probable identifications are that they lived in Libya and other considerations have led some to think that they lived south of Egypt or east of Egypt around the Red Sea. According to Nahum their mercenary soldiers also helped Nineveh. The fact that the descendants of Phut are not described would indicate that they do not occupy a major role among the Gentiles. The last son of Ham, Canaan, is obviously important to Biblical history and to the nation Israel. The firstborn of Canaan, Sidon, is prominent in Scripture and descendants of Sidon probably formed the inhabitants of the ancient Phoenician city of Sidon or Zidon located some twenty miles north of Tyre.
His descendants are first mentioned in the Amarna letters about b. It became a city located in the territory of Asher and later was given the modern name of Saida. The city and its inhabitants are mentioned about forty times in the Old Testament and a dozen times in the New Testament. Nat Cell Biol ; 12 : — Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation.
PREFACE TO THE SECOND AND REVISED EDITION, 1884. BY THE EDITOR
In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute. Cell Death Differ ; 15 : — Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis. Cell Death Differ ; 16 : — BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim.
Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell ; 7 : — Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation. Genes Dev ; 24 : — Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle.
Cell Stem Cell ; 15 : 37— J Mol Biol ; : — A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. Mol Cell ; 27 : — The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation. Immunity ; 35 : — The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation. MYSM1 is mutated in a family with transient transfusion-dependent anemia, mild thrombocytopenia, and low NK- and B-cell counts. J Allergy Clin Immunol ; e-pub ahead of print 25 July ; doi Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1.
Cell Death Differ ; 22 : — Deubiquitinase mysm1 is essential for normal fetal liver hematopoiesis and for the maintenance of hematopoietic stem cells in adult bone marrow.
Stem Cells Dev ; 24 : — Cell Stem Cell ; 9 : — Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature ; : — Global genomic profiling reveals an extensive pregulated autophagy program contributing to key p53 responses. Genes Dev ; 27 : — ROS and p a versatile partnership. Free Radic Biol Med ; 44 : — Maillet A, Pervaiz S. Redox regulation of p53, redox effectors regulated by p a subtle balance. Antioxid Redox Signal ; 16 : — Zhao J.
Cell Cycle ; 3 : — Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis. Cell Stem Cell ; 15 : — DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TApmediated induction of Puma and Noxa.
Chapter VII - Production of the mind-born sons of Brahma
Mol Cell ; 48 : — Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. J Exp Med ; : — Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death. Belle JI, Nijnik A. H2A-DUBbing the mammalian epigenome: expanding frontiers for histone H2A deubiquitinating enzymes in cell biology and physiology. Int J Biochem Cell Biol ; 50 : — Delbridge AR, Strasser A. A conditional knockout resource for genome-wide analysis of mouse gene function.
Widespread recombinase expression using FLPeR flipper mice. Genesis ; 28 : — Trimmomatic: a flexible trimmer for Illumina sequence data.
Monster Progenitor - TV Tropes
Bioinformatics ; 30 : — TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol ; 14 : R Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol ; 10 : R Bioinformatics ; 25 : — Robinson MD, Oshlack A. A scaling normalization method for differential expression analysis of RNA-seq data. Genome Biol ; 11 : R Brief Bioinform ; 14 : — BigWig and BigBed: Enabling browsing of large distributed datasets.
Bioinformatics ; 26 : — TM4: a free, open-source system for microarray data management and analysis. Biotechniques ; 34 : — Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma. Genome-wide RNA-mediated interference screen identifies miR targets in Notch-induced T-cell acute lymphoblastic leukaemia. Oncogene ; 19 : — Growth factor modulation of pmediated growth arrest versus apoptosis. Genes Dev ; 9 : — Mol Cell ; 47 : 38— The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes.
Related Progeny: The Progenitor Trilogy, Book Three (Progenitors Universe)
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